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phenobarbital improves toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers may perhaps enhance the metabolism of ifosfamide to its Energetic alkylating metabolites.Hypnotic doses of barbiturates never look to impair uterine action noticeably throughout labor. Comprehensive anesthet